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Studies show a fairly substantial difference, so its definitely a good idea to take L-citrulline instead of L-arginine

"The patient had used [melanotan II] before for over six years, in an effort to darken his skin each year before summer," the report's authors wrote

46 In keeping with this, transgenic mice overexpressing GIP exhibit increased bone mass and enhanced osteoblast activity at 24 months of age, whilst GIPR KO leads to decreased BMD, cortical thickness, and overall bone strength

Importantly, BIR markers have been observed in patients with DLB, further linking disordered insulin signaling with this synucleinopathy (36)